《首发与复发抑郁症患者记忆功能改善的比较》-理学论文，医学论文范文-论文范文参考-科学狗论文网

标题

首发与复发抑郁症患者记忆功能改善的比较

范文

谢新凤邓书禄李诗燕易芸杨晶雪兰寒菊

【摘 ?要】目的：比较计算机认知矫正治疗对首发与复发性抑郁症患者记忆功能的改善。方法：50例于2017年5月至2018年12月在广西脑科医院就诊的抑郁症急性发作期的患者按发病次数分为首发组与复发组，两组患者均接受药物草酸艾司西酞普兰+计算机认知矫正治疗（CCRT）治疗4周，分别在治疗前、治疗 4周后进行临床记忆量表（CMS）的评估，评价两组患者治疗前后记忆功能的改善。结果：治疗前两组患者的临床记忆量表（CMS）各项指标方面比较，差异无统计学意义（P>0.05）;与同组治疗前相比，两组患者治疗后CMS各项指标均显著改善，差异均具有统计学意义（t指向记忆 2.226，2.640;t联想学习4.410，3.936;t图像记忆4.521，2.718;t图像再认2.242，2.232;t人像特点回3.836，3.596;t记忆商数7.717，4.945; P<0.05）;经治疗4周后，首发组患者CMS各项评分指标显著优于复发组，差异均具有统计学意义（t指向记忆2.498，t联想学习2.724，t图像记忆2.399，t图像再认2.614，t人像特点回忆2.968，t记忆商数2.459， P<0.05）。结论： CCRT能改善抑郁症患者的记忆功能，而且首发患者效果更好。

【关键词】首发与复发抑郁症;计算机认知矫正治疗;记忆功能

【中图分类号】R749.4+1 ? ?【文献标识码】A ? ? ?【文章编号】1672-3783（2020）07-0033-02

【Abstract】Objective：To compare the improvement of memory function in patients with first and recurrent depression treated by computer cognitive correction. Methods：The 50 patients at the stage of acute depression were divided into the first episode group and the recurrence group according to the attack times in Guangxi Brain Hospital from May 2017 to December 2018.Patients in both groups were be treated by esitalopram oxalate and computer cognitive correction therapy （CCRT） for 4 weeks， the clinical memory scale （CMS） was used to evaluate the improvement of memory function before and after treatment. Results：there was no significant difference in the clinical memory scale （CMS） between the two groups （P > 0.05） before treatment. Compared with the same group before treatment， all indicators of CMS in the two groups were significantly improved after treatment， and the differences were statistically significant （tpoint to memory ?2.226 and2.640 ， tassociative learning 4.410 and 3.936，timage memory 4.521 and 2.718，timage recognition 2.242 and 2.232，tportrait feature recall 3.836 and3.596，tmemory quotient 7.717and 4.945，P < 0.05）; After 4 weeks of treatment， the CMS scores of the first-episode group were significantly better than those of the relapse group， with statistically significant differences （t Point to memory 2.498， t associative learning 2.724， t image memory 2.399， t image recognition 2.614， t portrait feature recall 2.968， t memory score 2.459， P < 0.05）. Conclusion：CCRT can improve the memory function of patients with depression， and the effect is better in the first episode patients.

【Key words】First episode and recurrent depression;Computer cognitive correction therapy; Memory function

抑郁癥被列为全球疾病负担最重病症之一[1]，是一种以情绪低落、兴趣减退、思维迟缓、认知功能损害为主要特征的情感障碍性疾病[2]。当前认为多数抑郁症患者存在显著的记忆障碍[3]，其中，记忆功能受损显著作用于抑郁症的康复，甚至降低康复后的生活质量。临床研究表明计算机认知矫正治疗系统（Computerized cognitive remediation therapy ， CCRT）对精神分裂症的认知功能受损具有明确疗效[4-6]，国内部分研究也认为，CCRT能有效改善抑郁症患者的认知功能，并影响其记忆功能。故本研究旨在探讨CCRT对抑郁症患者的记忆功能改善的效果，以及比较CCRT对首发与复发性抑郁症患者记忆功能改变的差异。

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